Yes, the one big problem is OB’s will tell you immediately how good/bad your room acoustics are. You do "hear" the room. My listening space is not ideal. Basically a square room with the hallway down the left side Speaker and a pocket where the entrance is and a lot of Glass on that side.You mentioned center fill as an issue. The way an OB system is supposed to work is that the rear firing information bounces off of the wall behind the speaker and thus arrives at least 10mS later than the first arrival.
If it does that the ear uses the delayed information to echo-locate, IOW to help out the sound stage. If it is less than about 10mS then the information contributes to harshness. As a general rule of thumb you want such a speaker to be at least 5 feet from the wall behind it. If less than this it won't image right because of the reasons I stated.