Moms battling cancer for the second time now. I wish you the best. I've been through a ton of speakers and am currently using Magnepan LRS's.
My advice, hget a pair of 1.7i's used for around $2k and any decent sealed 10" or 12" sub. If you dont love the Maggies, sell them for the same $ you bought thrm for and then look at some other speakers (dynaudio would not be a bad choice).
But honestly, if you've never had Magnepans, try a pair. They are the fastest speaker I have ever owned as well as being incredibly open / clear / transparent. The large, wall of sound is enveloping and engaging. They are really pretty cool speakers.