Depends:: and Depends.
If you're talking 'bare room' without anything in it, you can make it go either way. Lots of windows? Flat ceiling? Willing to install / tune room treatments?
http://www.marktaw.com/recording/Acoustics/RoomModeStandingWaveCalcu.html
above would be good place to start. You'll see that any room dimension of 1.5x another will produce same frequency results.
this is standing waves which result in loud/boomy or 'suckout' or lack of a specific frequency....some people will complain of 'lack of bass' in this case.
At over 5000ft3, it is a fairly large space. If you like it LOUD, you'll also need more juice or more sensitive speakers. Don't rely on a single sub, you'll need at least a PAIR, located asymmetrically.