Here's a thought, perhaps you should do neither! Pre amp tubes, amp drivers and power tubes all contribute substantially, and probably equally, to the sounds you hear. You need to decide what you want to change, sound wise. The sound you want to hear will determine your selection. Personally, I would start with my pre-amp and if that didn't give me what I wanted I'd start working on the amp, starting with the drivers. Leave the power tubes til last (due to the expense involved - but if you have smaller power tubes (read less expensive) you may have a couple sets of new production tubes about for contrast purposes). There are new production tubes that work well in amps but not so well in pre-amps. There are NOS tubes of moderate price that can work as well in either and there is some dreck. Then there is the expensive NOS stuff, which should be approached with caution, unless you are absolutely sure it will work well in your application. Usually its not a matter of "tube A" being better or worse than "tube B" its about how the tube will compliment your unit and your system and give you the sound you want to hear. Caveat emptor.