Musikdok, I have not tried the Zerostat on CD's, but I am certain that it would not hurt anything. At the very least, the CD should become less likely to collect dust particles that can interfere with the laser pickup. Regarding other tweaks, there are countless cleaners and treatments for CD. I saw Audio Research using a CD spray treatment, and upon discussing it with them, they are convinced it is worthwhile. ARC is a pretty conservative company, I doubt that they would say that unless they heard a significant improvement. I used to use the CD stoplight, sold by Audioprism, this green fluid could be applied to the edge (both center and outer) and supposedly stopped laser scatter from introducing errors in the circuit. I do know that it was easily audible after applying, but each of you must decide how much of this is for you. As far as the other comments posted here, concerning static, magnetics, etc. I would not be surprised if any and all of these played some role in reproduction. The CD format is totally electrical in its retrieval, but at the same time, powered by a mechanism (motor) not far removed from a LP turntable. I believe that all the things that are done to isolate, insure speed accuracy, and prevent excessive vibration in a LP turntable, probably would apply to CD. I also suspect that there are many electrical things happening inside a CD player, that we do not fully understand. Certainly there is no harm in experimenting with some of these tweaks, the costs involved are ridiculously low. As in all things in life, garbage in and garbage out. Even a small change at the front end of a system can result in a really nice improvement in the music.