Did you mean the USB cable is 10-12 feet? If so, I believe that may be approaching the limitations of the USB connection which is about 16 feet as I recall. You can use a repeater after that, but the first thing I'd try is a shorter cable. As Arni suggests, make sure if the M-Audio is getting power from the USB port, and that you are plugging directly into your computer and not into a hub or into your keyboard. I assume you are using the M-Audio as the DAC rather than to just stream the digital to an external DAC. Did the M-Audio come with software? If so have you checked all the settings? If the sampling rate were off you would not have clicking but a bunch of static. I use a Waveterminal USB device to stream audio from my computers to my DAC. I'm on a Mac and don't have any problems at all using my computer at the same time as I am streaming music. Only under the most memory-intensive applications on my laptop do I ever get a glitch now and then. On the desktop not a peep, but that is running about 1.5 gigs of RAM. I think the USB should be entirely adequate for streaming music. as there are many devices that do rely upon that interface.
Good luck! Keep us posted on what you figure out.
Marco
Good luck! Keep us posted on what you figure out.
Marco