It is almost impossible to generalise in this way.
LF bass response, accuracy, SPL level and dynamic range should all be better with a big speaker (if driver quality is maintained).
However, a big speaker with several lower quality drivers can sound worse than a small speaker with a higher quality driver.
Since most speakers sound quite different at high versus low SPL levels; there is often an optimum level for a particular speaker. Typically, a small speaker may strain at high levels, which sounds dull and compressed in the bass and harsh in the mid range. Conversely, a large speaker may sound dull or lack clarity in the mid range at low levels.
...other than physical size, what makes a speaker too large for any room..?
LF bass response, accuracy, SPL level and dynamic range should all be better with a big speaker (if driver quality is maintained).
However, a big speaker with several lower quality drivers can sound worse than a small speaker with a higher quality driver.
Since most speakers sound quite different at high versus low SPL levels; there is often an optimum level for a particular speaker. Typically, a small speaker may strain at high levels, which sounds dull and compressed in the bass and harsh in the mid range. Conversely, a large speaker may sound dull or lack clarity in the mid range at low levels.