Best speakers for compressed audio

I know that combining real sound quality and mp3's is a contradiction however I'm sure some solutions are better than others. My home system comprises of Linn speakers (in fact I have three pairs), a NAD pre-amp, Rotel power amp and Rega CD player. At work I have a 320 gig hard drive filled with mp3 and flac music files. I recently purchased a pair of Audioengine A5's which sound great but get interference from the office network. I would welcome suggestions as to how to optimize the sound from compressed audio files as the source. Thanks!