Is it possible to have to many tweeks in your system


I have tried a lot of tweeks in my system. Power cords, AC conditioning, isolation devices, racks, etc, etc.
I have found some to give an improvement in sound quality. Some just sound different and not better. And some just sound worse.

I am wondering is it possible to have to many tweeks in your system where one tweek cancels out the other. I have mostly heard that tweeks are a cumulative effort but I wonder in some situations can it have a negative effect?

taters
I'm sure you can have multiple things cancel each other out- you know, like putting a humidifier and a dehumidifier in the same room and letting them fight it out 
One thing to avoid is having two suspensions under one component. For instance, an isolation platform with any kind of "spring" under a suspended turntable. But that you probably already know!
I scrupulously avoid lead and Sonex, myself. Two of the most heinous materials ever to be foisted upon naive gullible audiophiles. I’m not crazy about Sorbothane either. Ye olde ERS anti EMI/RFI cloth? Forget about it! You can overdo Tube Traps, crystals but you can never have too many Mpingo discs. But those empty beer bottles lying around will definitely mess you up.