In a word yes, it matters tremendously. I need 3 such BNC 75 ohm cables in my DCS Paganini stack and upgrading to Transparent Reference XL made a big difference. Previously I had used AudioQuest Eagle eye. At nearly $3k a cable this is not cheap but most regard this transparent series as top of the heap on digital interconnects
also the power cord to the clock makes a big difference if you haven't already upgraded that
also the power cord to the clock makes a big difference if you haven't already upgraded that