From what I understand the only concern one truly has to worry about with two or more subs is that they are not placed in a way where one is out of phase with the other. By setting up multiple subs in ways where they generally mirror each other or sit along side/front walls equal distance from corners will generally have each sub work in tandem reinforcing the bass signal and keeping boom and nulls to less effect. Now of course if you have subs with a variable phase control you can with effort tweak the subs to work more in phase and thus positioning errors will not be quite as much an issue in terms of phasing.
Now of course two subs if not sitting in a best compromise situation for what may be determined as the best sitting locations for listeners can still aggravate boom and tubbiness of bass along with nulls in bass.
Dr. Toole suggests the best choice if budget allows (and factoring extra electricity useage) is FOUR subs each in a corner. They will cancel out well over 85% of the room effect of boom, tubbiness and nulls. They will provide the smoothest bass for the most listeners in room. On top of that they will work more efficiently as the corners reinforce their output causing the sub amps to work less hard. He suggests you may be able to settle for even smaller subs say 4-10's rather, than 4-12's or 4-15's. In such a case where you use FOUR subs one in each corner it no longer matters what your room is shaped like. It could be square, long rectangle, short rectangle, L shaped, or whatever.
If you want the easiest placement for multiple listeners with only TWO subs again setting each up down a wall and out of a corner and where each is relative to each other similar in the room placement you will get a better compromise for more listeners in room.
If you only have ONE sub the best thing to do is to put it as close to a mid placement on a wall, front, side or back to give the best compromise for multiple listeners in room. If only one listener will likely ever listen then put the single sub in a corner but understand once another listener or more then sits he/she/they will get a compromise in sound that may not be too pleasant for them.