Hi-Fi Tunig Fuses & Parasound A21

Hello,
I am thinking of replacing the stock fuses of Parasound Halo A21 and have a couple of questions for this audience who have hands on experience with fuse replacement.
1. It seems to me that the main fuse which is in the signal path would be the most important fuse to replace and would yield the max improvement in sound. Replacement of the 4 internal fuses in the rails not being in the signal path might be optional. Would you agree?
2. My fuse options are Hifi tuning Supreme and Synergistic Quantum Black. I read rave reviews of Hifi tuning fuses used in Halo A21 but not so much on the new Synergistic Black fuse. Did anyone have an opportunity to compare these two fuses?
3. I tried cleaning the main stock fuse with DeOxit Gold contact cleaner and the result was a very harsh sound as if the fuse was not broken in. I have also found that the sound changes with the direction of the fuse. In one way it is relaxed with a very clear mid-range specially the voice with a little loose bass. The reverse direction produces a very fast, punchy sound with a controlled bass but it had a tad hazy mid-range specially the voice.. I wanted to get both but it is not possible at least with the current stock fuse. Did anybody experience this behavior with the direction of the fuse be it a stock or an expensive audiophile fuse?
Thanks

FYI  The Parts Connexion has a sale on HifiTuning Fuses going on now.  I am awaiting the arrival of four silver star fuses.  They were 60% off!!

Thank you. I have just bought one Hifi Silverstar for the main fuse. Will try it and let you all know the result.

6.3A fuse ?

I have also found that the sound changes with the direction of the fuse. In one way it is relaxed with a very clear mid-range specially the voice with a little loose bass. The reverse direction produces a very fast, punchy sound with a controlled bass but it had a tad hazy mid-range specially the voice.. I wanted to get both but it is not possible at least with the current stock fuse.

This is not caused by reversal of the fuse but how it makes a connection. Quite often by reversing the fuse you get a better connection because the fuse sits better in its holder and thus there is a lower voltage drop across it.

IOW its the connection, not that its reversed. If the only way to get the fuse in the holder is by removing the fuse cap, you might not have much option but to reverse the fuse to see if the contact is better.