Will it work? Yes. But you will need a speaker selector for that. If you are going to be absolutely hard-core audiophile and do serious critical listening dont get a speaker selector and instead spend $219 and get an Emotiva A-100 it's a perfect solution for a second zone and you can take a loop out from the integrated to feed the second zone. You don't get trigger-level automation, that's the only thing. The Emotiva can turn on and off when it senses an audio signal so it may be ideal for you.
If you are going for a higher end integrated like the Simaudio pieces then you will have a sweet setup.
It just sounds to me from your posts that you are trying to fly through this. Forgive me if I misunderstand your posts as its just text without inflection. But if you have no control at all of your acoustics or speaker placement, it will seriously impair your system's potential. Speaker placement and room acoustics are absolutely critical. And it constantly amazes me how mediocre speakers can sound great and fantastic speakers can sound mediocre depending on the room, acoustics, and placement. So, I think it's fantastic that you have a sizeable budget; but I'd hate for you to spend $$$ and not get the enjoyment and quality you could if the system were setup properly. Again, if you have all that under control and planned out that's great and don't mean to be insulting.