What settings do people use with Lyra cartridges?

Atmosphere is totally correct. With my Herron  I find it sounds best wide open 

I like my Lyra Kleos set at 100 ohms the best.

mcgal,

I agree; Use 100 ohm setting for my Kleos on both my Pass Xono and Manley Steelhead.

The 100 ohm value suggests that your preamp is unhappy with RFI (Radio Frequency Interference) at its input.

The 100 ohm value detunes the RF circuit caused by the tone arm interconnect cable and the inductance of the cartridge. As a consequence, the optimal loading value varies from cable to cable. Of course, if your preamp is stable with RFI at its input, the loading value will cease to be a concern.