The "most foolish" loudspeaker tweak/upgrade ... is


I suggest Von Schweikert Audio's "ULTRA Internal Wire Upgrade" at a 'mere' $39,700..

ptss
The concept of twisted pair is nothing new, it's been known sonce the days of the telegraph, I.e., number of twists per inch depending on the frequency or gauss of the magnetic field or EMF. Basic stuff I learned in college all those years ago. Audio cable makers didn't invent this idea or discover it. it certainly doesn't add any cost to making cables. 
From our friend Wikipedia,

"Twisted pair cabling is a type of wiring in which two conductors of a single circuit are twisted together for the purposes of canceling out electromagnetic interference (EMI) from external sources; for instance, electromagnetic radiation from unshielded twisted pair (UTP) cables, and crosstalk between neighboring pairs. It was invented by Alexander Graham Bell.[1]"

My note: twisted pair cancels RFI/EMI, but not magnetic fields. Magnetism is a horse of a different color. Shielding, absorbing, rejecting, cancelling magnetic fields calls for something a little more uh, stringent.

@cdwallace3 Not quite. The primary factor (imo) is speaker efficiency.

If you have 102db/1w speakers (as I do), then their sensitivity to upstream changes are huge.

The more efficient your speakers, the more revealing they are.

That said, you’re not going to find high efficiency speakers that cover a large frequency range w/o spending a fair sum.

I got really lucky and got a pair of eXemplar Horns used. John Tucker won’t build another pair for less than $35k these days.