for interconnects, use balanced cables to avoid picking up any RFI and grounding issues
for USB cables the situation is more complex and a 'box' that addresses grounding, noise, and the ability to regenerate a properly clocked signal may have benefits
you really need some IEEEs who work on digital circuits in your family
AND... a double-blinded test with adequate statistical power is an issue for any putative differences "heard"
people who don't understand science are often spouting off on these forums, but worse is they are the lawful prey of consumer fraudists who sell them pseudo-technical sounding gibberish and expensive, but unproven, cables