Why drawbacks? It can be beneficial to use different wires.
kijanki --
As per above, exactly my experience as well. Hence my promoting this route.
It is done in internal biwire cables. Also, my Acoustic Zen Satori shotgun cables have markings "Hi" and "Lo" suggesting they are different.
I’m not claiming the "shotgun with dissimilar cable" approach hasn’t been used already, but I have rarely, if ever seen it mentioned as something that isn’t pre-built, and where separate cable lengths are used of different brand/type/conductor material, etc. There are literally a myriad of combinations to be explored.