Ground-loops don't generally cause harshness, only HF background noise. Some reclockers provide galvanic isolation, so eliminates ground-loop.
Cables make a big difference and you should be using the best I2S or the best S/PDIF you can get, without breaking the bank.
The problem with virtually ALL transports is that the S/PDIF output signal has a fairly long risetime. This makes it jitter-prone at the receiving DAC, and makes the requirement of at least a 1.5m long cable.
Faster risetime from a computer converter or a reclocker will reduce added jitter, but requires a really good impedance match at driver and receiver and the cable.
Steve N.
Empirical Audio