A friend of mine was having trouble with noise on his system, and asked me to come over and look at it. He had "tidied up" the back of his center by neatly tye-wrapping and using cable channel materials. It looked very nice, but that is what was causing all the problems. We took it all apart, separated the power carrying lines from the signal lines, and kept them loose but separate, and it went back to working OK again.
Crossing by 90 degrees as mentioned above reduces the cross talk coupling enormously. Cables will need to cross, so you keep them away from each other, and then make a run across at 90 degrees. Having some open hooks screwed in the back of the entertainment center allows you to drape the cable into the proper positions,