First compare the same interfaces, whether USB, Ethernet, AES/EBU or S/PDIF coax. You should obviously level-match using a SL meter. Tracks should all be .wav and high quality. Some should be non-music, like falling rain, tinkling glass, blowing wind, percussion, drums. Try Doors Riders on the Storm. Andreas Vollenwider. One track should have deep bass, one track should have serious dynamics. Limit it to 3 or 4 tracks.
Try going direct to your amps and also through your preamp or linestage with both. You may find one blows away the other if you go direct.
Steve N.
Empirical Audio