Now one thing I do not know is what occurs if that ratio is sky high, say 500 to 1 or so?No problemo, Uberwaltz :-)
It would be extremely rare for a problem to result from having too high a ratio, and in fact if that were occur it would most likely be the result of a design flaw in one of the components.
The only situation I can recall ever being reported in which a problem occurred from having too high a ratio was the one Ralph (Atmasphere) described in his posts dated 8-3-2012 in this thread. And that situation resulted from an unusual combination of circumstances involving a preamp and a power amp, and a marginally stable power supply in the preamp.
Barring a design flaw in a component, I wouldn't worry even if the ratio was 10,000 to 1.
Best regards,
-- Al