Fuses have no bearing on sound quality unless they are directly between the output stage of the power amps and speakers. Remember, it is the secondary of the amplifier’s power transformer that does all the heavy lifting (typically 5:1 current ratio relative to the primary winding), augmented by the filter capacitors on more demanding load peaks).
The OP’s problem is probably exacerbated by the design spec for his amplifier fuse leaning towards the conservative side, more judiciously protecting the amplifier. I suspect tolerance of the fuse in that case might be a factor also, making the likelihood of blowing a fuse even greater. If it were my gear, I’d take some current draw measurements to get an idea of how close to the threshold the amplifier is running. Consulting with the manufacturer would be prudent, in case they have come across other such cases and deemed that a change in fuse rating is warranted to mitigate nuisance blowing of fuses.
The OP’s problem is probably exacerbated by the design spec for his amplifier fuse leaning towards the conservative side, more judiciously protecting the amplifier. I suspect tolerance of the fuse in that case might be a factor also, making the likelihood of blowing a fuse even greater. If it were my gear, I’d take some current draw measurements to get an idea of how close to the threshold the amplifier is running. Consulting with the manufacturer would be prudent, in case they have come across other such cases and deemed that a change in fuse rating is warranted to mitigate nuisance blowing of fuses.