Not detrimental, but also no effective either.
Keep in mind that it is very difficult to work with thick cables as 0 AWG.
It is even more difficult to get a 2x 0 AWG or 4x AWG.
For the length, every time the length doubles, so shall the cross section. So if there is no other option, you will need double the thickness…
But if there is an option, you better keep the cable length short.
Another problem, with 0 AWG and above cables, is the weight they put on the binding posts. That is no problem if the amp and speakers are on the floor.
But if they get hanging 2' from ground, that might be a problem.