erik - Purifier?? I don't know what product this is. Do you mean the Short-Block?
There is no incompatibility with XMOS-based USB interfaces. Sometimes they need +5V from the USB cable depending on the design. The SB cuts this voltage. It doesn't matter because it out of production now.
I would highly recommend this product for USB:
https://sotm-usa.com/collections/sotm-ultra/products/copy-of-tx-usbultra-regenerator-1
This is the ONLY thing I have tried that makes my USB almost as good as my Ethernet interfaces.
Steve N.
Empirical Audio