I believe the weakest link in my system is the speakers which are causing me issues with inconsistencies whenever I play them i.e. they sound good one day and not so great the next.That can't be the speakers, unless your moving them around, or they are Electrostatics with dynamic bass drivers, as the ESL's can be less efficient on very humid days compared to dry days and with a dynamic bass driver the whole speaker can sound bass heavy on humid days and visa versa on dry days.
If none of these apply to you then it's your electronic chain (source to amp/s) that is your problem.
Cheers George