Conrad Johnson Premier 140 fuse is blown

If it was a fault in the fuse.

You must check at least with a meter or any signs of damaged components, likely resistors or whether any tube is bad.

Likely, a tube or more has shorted. This takes out some other components around the faulty tube and this short will take out the fuse.

There is only a very small chance it will work by just replacement, lest the time the new fuse blown again,  can take out more components.

Make sure that the speaker connection did not come loose. That will also blow a fuse!

Follow the advice in the manual, provided by the equipment manufacturer(as mentioned above).      

The first tube I would look at would be the rectifier tube if your amp has one.