The basics are pretty simple, in my experience and based on audio science. I've been fortunate to be able to experiment with a wonderful array of spaces:
* Sidewalls - the closer they are to the speakers the more your image is anchored on the speakers while forming a "U" between the speakers (speaker output is reinforced with short delay reflections). For best imaging, you should for all intents and purposes have no side walls within many, many feet of the speakers.
* Wall behind speakers: The further away, the more "depth" you will perceive when it is recorded on the recording. The closer behind, the less depth. (Of course, you have also to pay attention to room nodes for accurate bass reproduction.)
* Prevention of center "cross-contamination". Experiment with center reflections from the wall behind the speaker. To experiment, put a six foot high stack of empty boxes with one corner ("v") centered and facing out behind the speakers. This breaks up reflected diffusion from between the speakers. In a real room, this can be approximated many ways, including a "v" shaped two panel screen if needed.
This is the simplified basic. It can be approximated different ways with room treatments. If you are lucky, you can even arrange a living room this way.