@mikey8811 I was using similar optical isolation with dual opticalModules from Sonore each powered by its own SGC 5V power supply. I replaced the one downstream with the EtherRegen. Kept the opticalModule upstream. This change provided an audible positive SQ difference for me. EtherRegen gives us more than optical isolation. Read the technical details if so inclined:
https://cdn.shopify.com/s/files/1/0660/6121/files/EtherREGEN_User_Guide.pdf?90
Having said this, each system is different. You will need to try for yourself if you really want to know for sure.
https://cdn.shopify.com/s/files/1/0660/6121/files/EtherREGEN_User_Guide.pdf?90
Having said this, each system is different. You will need to try for yourself if you really want to know for sure.