There's definitely differences between speakers, but very few in terms of the process in getting them set up, which basically boils down to trying lots of different setups and going with the one you feel is the best trade-off.
The method I learned that has worked well many times is a three step process. First try lots of widely varying locations. In your case since you have a lot of room to play with I would think of a fairly large rectangle area each speaker can go. Also at the same time there may be an area you could use for listening. Try lots of combinations that cover the range both speakers and sweet spot can be in.
This first step isn't as hard as it seems because all you are listening for is bass response and tone balance. So no careful positioning, and no spikes (easier to move), but do play music with a good midrange and bass.
Second step, measure to make sure the speakers are symmetrical and equidistant to the sweet spot. Then experiment with toe-in to find the right balance between image focus and spaciousness. The right balance being like everything else whatever you like.
Finally go back and measure again, only this time being very precise. In some rooms you can measure off the walls to the corners of the speakers. In others you can use a framing square and string. A level comes in handy to make sure the speakers are perfectly level, as otherwise what measures perfect at the base may be off at the tweeter. The difference between good solid imaging and amazing palpable presence can come down to tiny fractions of an inch. Hard to believe. Until you do it.
Then, you know what? You wind up right about where pryso said. Main difference being doing it this way you know, absolutely know, that is where they sound the best. There is no second-guessing. And if at some time down the road you think you might want something a little more this or a little less that, well you know which way to go and how likely it is to work (or not) because you did the hard work up front.
