I started with finding the best seating position in my room. I did this by ear, listening for the best balance for a smooth and articulate bass response. Then I placed my speakers front to back for staging/depth while maintaining good bass balance , then distance from the sidewalls, listening to female vocals in mono for solidity and focus of the central image, and finally toe-in for a final check on tonal balance and detail. They ended up about 85% apart relative to my ear-to-tweeter distance and toed in to meat at a point about 4-5 feet behind my ears.
When this was complete, I then checked speaker height/rake angle and toe-in angle with a laser pointer aimed at marks on the back wall. Finally, I checked the distances from the tweeters to side walls and tweeters to a center point on the back with the laser measuring device. Everything is to the nearest 1/16th of an inch. Sounds pretty anal, but this last step with the laser pointer snapped imaging and focus in place and the speakers disappeared to a much better extent than before.
This procedure is basically described in Jim Smith's book, "Get Better Sound." I had tried various test tracks, listening tones, etc, but always became frustrated with a lack of progress. I did the set up listening to real music and following Jim's advice. I found it worked best for me.