Edit: I see that millercarbon posted while I was typing... oh well, hopefully this won’t muddy the waters too much...
I’d suggest placing one of the REL subs along one of the side walls, closer to the back of the room than to the front, but not the same distance from its nearest corner as either of your mains.
Place the other REL sub along the back wall, closer to the other other corner, and again not the same distance from its corner as either of the other three.
If you have the option of inverting the polarity on the REL sub that is farthest from the mains (phase = 180 degrees), I suggest doing so.
For subs which are closer to your ears than the main speakers, I suggest not running them up any higher than 80 Hz, and less than that if the lowpass filter in those subs is less than 24 dB per octave. What you want to avoid is, the subs passing upper bass/lower midrange energy loud enough for give away their locations. Since they are closer to your ears than the main speakers, you ear/brain system will tend to hear them as the source of these sounds, which is why we want to roll off their top end aggressively.
If you are doing this by ear, here’s what I suggest:
First adjust the level (loudness) of your subs for best sound. You want them all at approximately the same loudness, so that all are approximately equal contributors. How loud the subs are makes the biggest difference, so we do that first.
Next adjust the low-pass filter frequencies of the subs. This makes the next biggest difference.
If you have phase controls, adjust them last. This makes the smallest difference.
Now cycle back through this sequence several times. In particular, setting the level may take a long time because the ear is especially sensitive to small changes in sound pressure level in the bass region.
Best of luck!
Duke