It does take a decent size room I think, but I found it took less effort to get them (the NX-Otica with triple-stack OB servo subs in my case) to sound quite good compared to conventional box speakers I've owned.
I have a fairly big room (17' x 29') that is reasonably symmetrical, so I have plenty of space to get them out into the room. I set them up about 7' from the back wall and 4' from the side walls and they sounded great. I tried moving them around a bit, but other than some toe-in tweaks, they are pretty much right where I set them up initially.
I have used Room EQ Wizard to set up the sub amps, which makes it MUCH easier to get them dialed in. But again, I haven't found the need to move the subs around to get good sound. The servo amps provide lots of flexibility in controlling level and phase and also include a single frequency parametric equalizer which I used for one channel to smooth out the bass a bit. The other channel didn't need it.
I do have a well treated room which helps, but I initially set them up before I had any treatments and they still sounded awfully good. The treatments sharpened the image and smoothed out the bass response a bit, but I think I would have been happy with the sound without most of the treatments. The tube traps in the corners behind the speakers were the first thing I added and made the biggest difference.