First off, what is the room construction?
Basement, 2nd floor, interior/exterior wall?
All of these affect transmissive coupling.
20 foot unbalanced interconnects with a low impedance output pre-amp into 10x amp impedance will be fine. Canare Star-Quad with screen connected at pre-amp only is excellent.
Short speaker cables are almost always preferred over long. Increasing diameter only helps R, the least worrisome of LCR.
Basement, 2nd floor, interior/exterior wall?
All of these affect transmissive coupling.
20 foot unbalanced interconnects with a low impedance output pre-amp into 10x amp impedance will be fine. Canare Star-Quad with screen connected at pre-amp only is excellent.
Short speaker cables are almost always preferred over long. Increasing diameter only helps R, the least worrisome of LCR.