don’t mind us tired old hacks here on this board doing a little keyboard jousting in the late night... some joust better than others when scotch or burgundy or ........ is involved :)
what you will hopefully take away substantively from here is that given the ref 6 uses the 6550 in the ps voltage regulator function (and not a primary signal amplification function) replacing that tube for hopes of better SQ is a ’maybe’ proposition - certainly more of a 'maybe' than upgrading the tubes actually handling the music signal (even though that can’t be done on your unit given the 4x 6h30p’s...)
but yes, in practicality, it all matters (more or less is the main issue at hand) and it is just one tube, so it’s hard to waste too much money chasing a ’maybe’ in this case - i would still suggest checking in with greg at arc to get his take/advice - they made the amp, their input is valuable
my post below was only sarcastically referring to your ref 6 as a p-o-s -- hopefully you don’t take that seriously, we all know it is a lovely piece, one of the very best - i have the ref 3, love it, can only imagine how sweet the ref 6 sounds
cheers and good luck