No, I would never consider trying it. I think between this thread and the sister thread below, you just about covered it all. It is just not practical to use large gauge wires in most installations.
https://forum.audiogon.com/discussions/how-to-select-a-good-speaker-cable?page=4
https://forum.audiogon.com/discussions/how-to-select-a-good-speaker-cable?page=4