If I am extremely stressed or fatigued, my system just doesn't sound right - as you describe unfocused with flat dynamics. Over several years, I'd experienced this with frustrating irregularity. Then I discovered that when I ingest a B-complex multivitamin the night before, my system always sound oh so right, glorious, the following evening. I have reproduced this phenomenon enough times that I cam convinced of the causality. From a medical standpoint (I am a physician) a logical explanation can be made, having to do with neurotransmitter depletion and general neuronal fatigue. As an aside,I have completely foresworn any alcohol in my diet for 5 years now; for me, alcohol consistently smears and thoroughly ruins the critical listening experience, even in small doses.