How are most audiophiles going from streamers to DACS

I agree with Herman.  If you have a Node 2i, then you are limited to coax or optical.  No USB.

I have always had better results with coax in most applications over optical.  My Node is no exception.  Per the review of the Node 2i by Audio Science Review, the SINAD is better with coax than optical, but that could have been an issue with the sample reviewed.

I have a Node 2i connected to a Denafrips Terminator via coax.  Much better results than the internal Node DAC.  In addition, I found that feeding the Node with an UpTone etherRegen added clarity and more soundstage depth.  Sadly though, it still does not compare with the sound quality of my Oppo 105.  I think there is limitations to the Node as a streaming device.

80% of my listening is hi-res streaming from Qobuz and Tidal 

My limited understand of the hierarchy of good, better, best guidelines is as follows, and in all cases the shorter the cable the better 

optical, coax, USB, I2S

I've tested all of them and have gravitated to I2S

This is one of the areas where the symmetry dance between your components is important

The SQ of entry level electronics typically will sound their best when using good cables but great cables will not promote entry level electronics to reference grade sound

Optical should be the best in theory, but it's probably the worst because there isn't a good interface available, as far as I know everything in audio is toshlink.

Optical for a CD transport, coax for anything else. 

Agree with reclocking.  The transmitter and receiver are your limitation, therefore avoid bandwidth limited optical and go USB, possibly coax. Coax is TEM00 and USB is twisted pair, at least it better be.  But this is digital so the cable bandwidth is not that critical as analog, and if you mismatch cable impedance, which is never perfect, your error correction from cable reflections, unless your connection is under 6", should give you 100% of your signal. I get no errors in my hi res system.