4, family room?
2 for the kitchen
2 for the patio?
Depending on the speaker type, 70v PA style system. I'm pretty sure you can run it how ever you want. That part depends on what the source amplifier can do and is made for. Certain amps are made for just this type of set up?
I suggest calling Parts Express and tell them what you have they will tell you exactly the type of speakers that will be best for you.. Options, ay?
They have 4-12 station amps, with YOUR phone in control. Weather proof drivers for outside.. Remote vs Hard wire vs both..
I'm not getting a clear picture.. Parts Express is your friend though..
A single receiver and 4 pairs of wires? Something like that..
Regards