I have tried this power cable with 22 gauge and 18 gauge wires as well.
22 gauge sounds etched, treble is piercing and bass is affected. (At least on my system)
18 gauge sounds too thick, treble is attenuated.
I don’t know exactly why this is the case, but 20 gauge is the best, and is the goldilocks zone.
I found it to be very neutral, and has fantastic resolution.
The Litz construction, say over a simple stranded wire, has audibly less distortion.