The problem is PCs are simply not created with noise reduction and power conditioning in mind.
Correct. Which is why i advocate simply isolating it and creating a dedicated low noise power supply on the "clean"side and allowing the Mac streamer to be dirty. trying to fix the computer will have diminishing returns (but running of battery makes a huge difference, with lots of limitations). This is why i wanted to know precisely what you tried and didn't.
NUCs are actually quite good if dedicated and with dedicated,and split/isolated power. RPis make good bridges (but start with the Pi4 or you will fight a lot of architectural issues). I mean, have you looked at what's inside the box of many streamers? Often a NUC or a Pi (as embedded).