If room size was not an issue and large enough, I'd have full size speakers (and probably still augmented with multiple subs). Generally speaking, a big speaker simply sounds bigger to me most of the time; there are well-designed exceptions.
But big speakers in a too small room sounds like a bad combo. My (gone) Dynaudio Sapphires could fill and play our 3500 cu. ft. living space set far apart however I now have Raidho D2s set in a nearfield 8' triangle and they are great. I don't think they'd fill the room, especially at volume, but I know they will work in smaller rooms if needed at some point. The joy in this little D2 floorstander is it cleanly digs to 30Hz and flat, in my room. So the subs are left turned off a lot.
I can easily see rooms where a standmount and subs may well be best but a well designed small tower will image every bit as well as a monitor in my experience. It would only be a small room dictating my move back to bookshelf speakers, and even though the Raidho D1s I had at home on audition were really amazing, the D2s are simply better; it's cabinet volume (and one more tiny mid-woofer).