I could not advise you on that since I have never used i2s myself. From what people say, i2s is superior over S/PDIF. However, some things to think about:
i2s - this requires a very short cable (1-2 feet). The interface does not work well with longer cables. Also, the largest awg conductors you will see are about 24awg in the largest HDMI cables.
AES/EBU - you can run this very long (15-20 feet is no problem). It also opens you up to a larger selection of cables and also cables that have much larger conductors (like 18 or 19 awg). In my experience, this gives you the best bass and depth of sound.