How Big of a Difference?

I'm not surprised you didn't hear a difference between the USB cables ... that's because there IS no difference. Any decent USB cable brings the 0's and 1's to the other end perfectly fine without errors.

With speaker cable there could be audible differences, given the rest of your setup is capable of bringing out the nuances. But it'll be subtle ... so subtle that only few people with almost absolute hearing will be able to spot them. These people exist, just like there are people who can name the vineyard when they smell and taste a wine, or the 'nose' of a perfume brand, who designs the fragrances. But these people are rare and are well trained ... the question is if you can hear the difference.

I'm not surprised you didn't hear a difference between the USB cables ... that's because there IS no difference. Any decent USB cable brings the 0's and 1's to the other end perfectly fine without errors.

With speaker cable there could be audible differences, given the rest of your setup is capable of bringing out the nuances. But it'll be subtle ... so subtle that only few people with almost absolute hearing will be able to spot them. These people exist, just like there are people who can name the vineyard when they smell and taste a wine, or the 'nose' of a perfume brand, who designs the fragrances. But these people are rare and are well trained ... the question is if you can hear the difference.

I am much better with the wine than with the cables.

I would not waste even a cheap bottle on a USB cable, unless it had a good return policy.

Amazon cables Suck , period , blue jeans are better you want a solid cable 

that’s a Big step up for reasonable monies Wireworld Equinox interconnects, speaker cables ,  very good value even their starlight Ethernet , usb cables excellent vaues and sound very respectable , one level from their top which has 4 levels .

I do Not hear a difference between cables on the floor as opposed to elevated....therefore they will stay on the floor...

I was not a believer in speaker cables, power cords, etc.  However, I worked with a very knowledgeable sales person at The Cable Company.  I ended up spending $4,000 on power cables, speaker wires and digital cables.  I was amazed by the sound quality after adding a $700 power cord to my ARCAM AVR550 and purchasing Synergistic Research Atmosphere Level One speaker cables for $1,500.  I was amazed by a significant change in detail.  I could hear cymbals in greater detail.  At first voices sounded harsher, but things settled down after I had put a few hours on them.  I thought people were crazy who believed in buying expensive high grade cables.  Carbon Miller was a big help because he told me to think of cables as components.  The first thing you should do is get rid of those cheap noisy speaker wires and purchase some better speaker cables.  The Cable Company has a library with cables you can try before making a purchase.  I think you will be amazed by the sound quality.  This service to try cables first certainly is fair.  Don't listen to those who preach expensive cables are a waste of money,  If this were the case cable manufactures will be out of business.  You have nothing to lose by at least trying them first.  Ask for Steven and tell him I sent you.