Signal cables do make a huge difference from one brand to another with Thiel speakers at least in my experience with my 3.7s.
I have gone from Gryphon VIP IC and SC to Cardas Clear Beyond IC and SC.
The difference is night and day, Clear Beyond cables are in a league of it's own.
The synergy with my 3.7s is mind blowing, never heard such level of weight and clarity in the bass region before.
Musicality is second to none, same with depth, soundstage, air, texture and so on.
Best cables i've ever heard to date by a wide margin and i can even say best component upgrade i've ever done in my life.