Definitely, I’ve had cables that change the whole listening experience for better or worse. Lower gauge cables seem to make a big impact. Going from 14/15 gauge down to something half that will provide so much more depth. A low gauge power cord, same thing.
One thing that is supposed to really change things is doubling interconnects with a y splitter. I’m not sure why this is considered so effective other than halving the resistance, but the “Schroeder Method” as they call it has been a game changer for some.