I've owned and sold Dynaudio Excite X12s and the floorstanding Sapphires (5 yrs) and although both were fine, I'd far prefer Joseph Audio, and love TAD floorstanding speakers as well, but am not familiar with the ME1. (Get a sub if needed.)
Both seem more long-term listenable to me than the Dynaudio models I owned.
You have some nice models to think about, and listen to. Good luck.