I've used a couple of versions of Anthem's ARC over a decade or so, with many loudspeakers. On general principles, I turn it on only if the positive effect on smoothing in-room frequency response seems "worth it" and the better the resolution of your system is, the easier it is to hear the software doing its thing.
Three observations:
1. After the measurements are made, I inspect the in-room response curves and apply RC only up to the lowest frequency at which it seems to be making a meaningful difference. Ideally, no higher than 500Hz, never more than 2000Hz.
2. Attempting to correct a dip in FR is much less likely to help the cause than a judicious trim to a peak.
3. The benefits for a multichannel system are especially evident.
4. Having capable DSP room correction won't eliminate the need for room treatment with physical measures in certain situations.