I am fully aware of the limitations of the DAC in the Node 2i as agd 101 pointed out. It's serviceable but not great.
I have a Node 2i (although it hasn't been plugged in for a while.) Seems to me, its weakness isn't so much its DAC as its preamp capabilities. Specifically, its volume control. I've A/B compared a feed from the Node 2i via (A) its digital outputs and (B) its analog outputs. From "A", I was hearing the DAC in a more expensive downstream component (equipped with the ESS 9028 chip IIRC). From "B", I was hearing the DAC in the Node 2i. I noticed no difference in SQ. YMMV.
However, when I've switched from digital/software volume control in the Node 2i to analog or hybrid digital/analog volume control in a downstream device, I noticed a rather significant SQ improvement. Again, YMMV (and maybe I'm not remembering every detail of these comparisons). But I suspect you could improve the SQ by moving the volume control downstream, whether to (1) a decent dedicated preamp, (2) a better streamer/DAC/preamp box, or (3) a decent integrated amp. Currently, I'm using option 2 (a Matrix Audio Element X). If I wanted to try option 1, I'd be considering the Benchmark LA4 (a line amplifier that goes for about $2600 and gets very strong reviews.)