Do speaker cables really make a difference ?

if you can hear the difference, they do

OK assuing all the wires attached to the components are top shelf(and likely costly)and the synergy is perfect. What happens to the sound(signals) when the signals  meet the cheap zip cord like internal speaker wires?  It can't be good can it, How can it be good?

What happens to the sound(signals) when the signals  meet the cheap zip cord like internal speaker wires?

1 - the internal wiring of speakers is not as important, because (a) they are very, very short runs, way shorter than the speaker cables, and (b) they are inside the cabinets (not subjected to other environmental factors associates with the speaker wire going from the amp to the speakers).

2 - Good speakers use good internal wire, and not crap / zip cords.

Hopefully I did not waste my time writing this, as I smell a snarky question, like you folks always do. Oh well...

Once you try Fidelium in your rig you'll have your answer. 

  I see the “ lamp cord comment “ by the same contributor.  So do you still run the thin red, white and yellow interconnects? According to you , it’s just wire. Why do you roll tubes ? They’re just metal and glass.  Some poor village is deprived of an idiot …. Go home.