Ted Smith, PS Audio DirectStream DAC inventor uses / used USB on the original DirectStream DAC (there’s a new version now with galvanic isolation). Ted believed that the biggest issue with USB is the noise from the 5V power generated by the source. Unfortunately the DAC requires the 5V to be recognized but an inexpensive work around is available. A powered USB 2.0 hub and a power blocker adapter removes the computer’ 5V allowing the hub provides its own.
My experience is that it improved the sound quite a bit. I2S into the latest version of the DirectStream is probably better but defiantly not what I would call an inexpensive upgrade.